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  首 页 >> 生物试剂 >> 生化分子 >> 抑制剂 >>
【产品名称】
 SB 203580, Free Base, >99%
【订购货号】
 L111716
【产品CAS号码】
 152121-47-6
【规格/价格】
 
【预计到货时间】
 30 天
【产品详细说明】
【本产品仅供科学研究使用】
【更新日期】 2012-5-15  

M.W. 377.43

C21H16FN3OS

[152121-47-6]

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 100 mg/mL; soluble in ethanol at 12.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Appearance:  white to off-white solid.  Disposal:  A

  • Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK.  This kinase is a homolog of MAP kinase.  Gallagher, T.F., et al.  "2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis."  Bioorg. Med. Chem. Lett. 5:  1171-1176 (1995).  Cuenda, A., et al.  "SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1."  FEBS Lett.. 364:  229-233 (1995).  Hazzalin, C.A., et al.  "Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli."  Oncogene 15:  2321-2331 (1997).

  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.


SB 203580, Free Base

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