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【产品名称】
 PD-L2(生物素化)抑制剂筛选分析试剂盒,PD-1:PD-L2[Biotinylated] Inhibitor Screening Assay Kit
【订购货号】
 B277327
【产品CAS号码】
 无
【规格/价格】
 
【预计到货时间】
 30 天
【产品详细说明】
【本产品仅供科学研究使用】
【更新日期】 2015-1-12  

PD-1:PD-L2[Biotinylated] Inhibitor Screening Assay Kit

Catalog #: 72004
Size: 96 reactions
Background:
Cell signaling through the PD-1 receptor upon binding the PD-L2 ligand attenuates immune responses and is exploited by both tumors and viruses.
Description:
The PD-1:PD-L2[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this signaling. The key to this kit is the high sensitivity of detection of biotin-labeled PD-L2 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, PD-1 is coated on a 96-well plate. Next, PD-L2 is incubated with PD-1 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can then be measured using a chemiluminescence reader.
Supplied As:
Kit comes in a convenient 96-well format, with biotin-labeled PD-L2, purified PD-1, streptavidin-labeled HRP, and assay buffer for 100 binding reactions.
Contraindications:
DMSO >1%, strong acids or bases, ionic detergents, high salt.
Format:
COMPONENTS

Storage / Stability:

Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.

Application(s):
This kit is useful for screening for inhibitors of PD1 binding to PD-L2.
Reference(s):

1. Molnar, E., et al. Proc Natl Acad Sci U.S.A. 2008, 105: 10483-10488. 
2. Keir, M.E., et al. Annu. Rev. Immunol. 2008, 26: 677-704.

Warning(s):
Avoid freeze/thaw cycles.
Scientific Category:
Cell Surface Receptor/Single-pass Transmembrane Protein
Product Type:
Assay Kit
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