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  首 页 >> 生物试剂 >> 细胞因子及蛋白 >> 重组蛋白 >>
【产品名称】
 Activin B 植物来源无动物成分
【订购货号】
 O377195
【产品CAS号码】
 无
【规格/价格】
 
【预计到货时间】
 30 天
【产品详细说明】
【本产品仅供科学研究使用】
【更新日期】 2014-9-1  

Activin B, human, recombinant

Activin B is a non-glycosylated cytokine that belongs to the TGFß superfamily. It is involved in a wide variety of biological processes including hematopoiesis, immune response, neural cell differentiation, wound repair and morphogenesis. The Activins form homodimers (e.g. AA; BB) and heterdimers (e.g. AB) and can activate the Smad pathway by signaling through heterodimeric typeI/typeII serine/threonine kinase transmembrane receptors. Activins are also important for production and regulation of several hormones such as FSH, Prolactin, ACTH and oxytocin. Activin B is synthesized by a wide spectrum of cells including bone marrow cells, skin cells, vascular smooth muscle cells and cells of the reproductive system.

 

Lot Number

 

0N-1-117-7121

 

Available Sizes

 

10µg, 25ug, 100ug

 

Source

 

Produced by transient expression in Nicotiana plant

 

Formulation

 

Lyophilized from Tris HCl at pH 7.4

 

Purity

 

Greater than 95% by SDS page analysis.

 

Reconstitution

 

Note: Always centrifuge the vial before opening. It is recommended to reconstitute the lyophilized protein in sterile water to a concentration of no less than 50 µg/ml. Due to the protein nature, dimmers and multimers may be observed. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

 

Stability

 

The lyophilized protein, though stable at 2-8°C in the short term, is best stored at -20°C. Reconstituted protein should be used immediately or stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

 

Biological Activity

 

Bioactivity is assayed by measuring the ability of recombinant human Activin B to inhibit proliferation of mouse plasma-cytoma cell line (MPC-11). The ED50 value for this effect is typically below 5 ng/ml.

 

Endotoxin Level

 

Endotoxin level is less than 0.05 EU/ug as measured by LAL method.

 

MAT assay

 

 

Molecular Weight

 

Single chain of 14 kDa. Recombinant human Activin B contains a protein chain of 113 amino acids and a 10 aa Histidine-based tag for a total length of 123 aa.
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