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【产品名称】
 BMP-2 植物来源无动物成分
【订购货号】
 O377196
【产品CAS号码】
 无
【规格/价格】
 
【预计到货时间】
 30 天
【产品详细说明】
【本产品仅供科学研究使用】
【更新日期】 2014-9-1  

BMP-2, human, recombinant

Human Bone Morphogenetic Protein-2 (BMP-2) is a member of the TGF-beta superfamily of cytokines that effect bone and cartilage formation. Human BMP-2 is a disulphide linked homodimeric protein. BMP-2 plays an important role in various processes during embryonic development, including induction of bone and cartilage growth and regeneration, cardiac cell differentiation and epithelial to mesenchymal transition. BMP2 promotes osteogenic and chondrogenic differentiation from mesenchymal cells, stem cells, and vascular smooth muscle cells. BMP-2 has great potentials for regenerative and medical therapeutic applications.

 

Lot Number

 

0N-1-026-7129

 

Available Sizes

 

10µg, 100µg, 1000µg

 

Source

 

Nicotiana tobacum

 

Formulation

 

This product was lyophilized from a concentrated sterile solution containing 25 mM MES, pH 6

 

Purity

 

>95% pure

 

Reconstitution

 

Note: Always centrifuge the vial before opening. It is recommended to reconstitute the lyophilized protein in sterile water to a concentration of no less than 50 µg/ml. Due to the protein nature, dimmers and multimers may be observed. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

 

Stability

 

The lyophilized protein, though stable at 2-8°C in the short term, is best stored at -20°C. Reconstituted protein should be used immediately or stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

 

Biological Activity

 

Each batch of ISOkine™ growth factor is tested for bioactivity and verified to have comparable activity to a commercial source. The bioactivity of ISOkine™ recombinant human BMP-2 was determined by its dose dependent induction of alkaline phosphatase production by ATDC-5 mouse chondrogenic cells. The ED50 value for this effect is typically below 75 ng/ml corresponding to specific activity of > 1.3 x 10e4 U/mg. Optimal concentration should be determined for specific applications and cell lines.

 

Endotoxin Level

 

Endotoxin level is less than 0.05 EU/ug as measured by LAL method.

 

MAT assay

 

 

Molecular Weight

 

Bone Morphogenic Protein-2 Human Recombinant produced in transgenic tobacco plants is a homodimeric polypeptide chain containing 114 amino acids and has a molecular mass of 26 kDa.
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